Ground was broken for the "Holy Angels School and Parish" at the end of January 1960 and staffed by the Franciscan Fathers. The buildings were sufficiently constructed to open their doors for the first students to attend the new school in the fall of 1960. The school's gymnasium was decorated to serve as a church and soon Fr. Simeon Cleves, OFM, celebrated Sunday Masses there. Holy Angels was given the status of a 'mission' of Sacred Heart Parish. 

By the following year, the mission had grown sufficiently to be designated a parish with a resident priest, and it was named to that status by the Bishop of Amarillo on August 1, 1961. Fr. Cleves served as priest-in-charge. A few months later, Holy Angels became a part of the newly established Diocese of San Angelo. 

By the late 1970's, the second phase in the development of the parish took place--the construction of a permanent church for the congregation. Ground was broken in November of 1981 and the new church was completed in August of 1982 with the church being dedicated on August 15, 1982. 

In June of 1996, Holy Angels completed a major renovation of the Parish Hall, construction of what is now the Adult Faith Center, and the addition of two parking lots adjacent to the school complex.
 
On February 8, 2002, ground was broken for a new 1,000 seat church.  As part of a 2-phase project the 1982 church was transformed into the Education Building and a 2,800 sq ft Recreation Center was added to the facility.  The new church was dedicated on August 10, 2003.

Throughout its history, Holy Angels' growth has mirrored that of the southwest part of the city. From its charter membership of about 200 in 1961, parish membership has grown to 1470 registered families and 3500 members.

The following priests have served Holy Angels as Pastors: 
Fr. Simeon Cleves, OFM, August 1961-January 1962 
Fr. Raymond Soper, OFM, January 1962-August 1963 
Fr. Alfred Hudepohl, OFM, August 1963-August 1966 
Fr. Pius Winter, OFM, August 1966-June 1969 
Fr. Timothy Murphy, June 1969-August 1982 
Fr. Mark Woodruff, August 1982-October 1986 
Fr. Serran R. Braun, October 1986-June 1993 
Fr. Charles C. Greenwell, Ed.D., July 1993-Present 

The following priests have served as Associate Pastors: 
Fr. Melvin Hotel, OFM, August 1964-June 1969 
Fr. George Conners, June 1969-March 1970 
Fr. Louis Droll, March 1970-January 1971 
Fr. Peter Vergauwen, August 1980-August 1982 
Fr. Patrick Flood, August 1982-August 1985 
Fr. Vince Wiggins, June 1983-August 1985 
Fr. Maurice Voity, October 1986-May 1989